New Derivatives of pyrazolo 3,4-d pyrimidine as Anticancer Drugs.

摘要

1.- Substituted pyrazolo [3,4-d] pyrimidine derivatives of the formula I, and pharmaceutically acceptable salts thereof, characterized in that n and m are 1, 2 or 3; W is an individual bond, alkenyl, alkynyl, NH, S, SO, SO2, O, C = O, or an amide group: each R1 is independently selected from hydrogen, halo, hydroxy, amino, hydroxyamino, carboxy, nitro, guanidino , ureido, carbamoyl, cyano and trifluoromethyl, or each R1 is independently selected from the group consisting of C3-C6cycloalkyl, C1-C6alkoxy, C3-C6cycloalkoxy, (C1-C6) alkoxycarbonyl, aryloxy, heteroaryloxy, C1-C6thioalkoxy, C3-C6alkoxy , thioaryloxy, thioheteroaryloxy, nitro, amino, N-mono (C1-C6) alkylamino,N, N-di (C1-C6) alkylamino, formamido, amido, acetamido, hydroxylamino, C1-C6alkoxyamino, hydrazino, trifluoromethyl, trifluoromethoxy, C2-C6alkenyl, C2-C6alkynyl, aryl, heterocyclyl, fused aryl and fused heteroaryl ; or each R1 is independently selected from R3-sulfonylamino, phthalimido- (C1-C4) -alkylsulfonylamino, benzamido, benzenesulfonylamino, 3-phenylureido, 2-oxopyrrolidin-1-yl, 2,5-dioxopyrrolidin-1-yl, and C2- C4alkanoylamino, and wherein the benzenesulfonylamino or phenyl or phenoxy or anilino or phenylsulfanyl substituent on R1 may optionally have one or two halogens, (C1-C4) alkyl, cyano, methanesulfonyl or (C1-C4) alkoxy substituents,o cualquiera de dos R1 tomados conjuntamente con los carbonos a los cuales est n unidos comprende un anillo de 5-8 miembros que comprende al menos uno o dos hetero tomos seleccionados de ox geno azufre y nitr geno en donde los grupos alquilo y porciones alquilo de