Type 1-2 polypeptide, with fast activity and more effective treatment for cancer and acute infection

摘要

The current invention refers to the polypeptide homologous to IL-2 human, but it has been mutated due to several amino acids. These mutations greatly reduced the ability of these peptides to stimulate T-regulatory cells (TCD4 + CD5 + Foxp3 +) in vivo and in vitro, and made them more effective in the treatment of malignant tumors. The invention also includes the therapeutic use of these mutants alone or in combination with vaccines,In the treatment of diseases such as cancer or infection, t-regulated cell activity is related. The invention also relates to the disclosure of specific peptides of amino acid sequences in the invention, and in another aspect, the invention relates to pharmaceutical ingredients that take the disclosed peptides as an activity principle. Finally, the present invention relates to therapeutic uses for the synthesis of transmitted polypeptides and drugs, because it regulates the immune system for diseases such as cancer and chronic infectious diseases.