4- (PYRIDIN-4-YL) -1H- 1,3,5 TRIAZIN-2 OLDER DERIVATIVES AS GSK3-BETA INHIBITORS FOR TREATMENT OF NEURODEGENERATIVE DISEASES

摘要

A triazinone derivative represented by formula (I) wherein: wherein: Z represents a bond, a carbonyl group, a methylene group optionally substituted by one or two groups chosen from a C 1-6 alkyl group, a hydroxyl group, a C 1-6 alkoxy group; R1 represents a 4-pyridine ring; R2 represents a hydrogen atom, a C 1-6 alkyl; R3 represents a hydrogen atom, a C 1-6 alkyl group; R2 and R3 may form together a 6 membered cycle with the nitrogens caring R2 and R3 optionally substituted; R4 represents: a phenyl ring, being optionally substituted; n represents 0 to 2; in form of a free base or of an addition salt with an acid. These compounds are useful as GSK3-² inhibitors.