u0433u0443u043cu0430u043du0438u0437u0438u0440u043eu0432u0430u043du043du043eu0435 u043cu043eu043du043eu043au043bu043eu043du0430u043bu044cu043du043eu0435 antibody, specific to the CD20 - u0430u043du0442u0438u0433u0435u043du0443, u044du043au0441u043fu0440u0435u0441u0441u0438u0440u0443u0435u043cu043eu043cu0443 b - u043bu0438u043cu0444u043eu0446u0438u0442u0430u043cu0438

摘要

the invention belongs to the biotechnology and medicine, in particular to immunology, and can be used for the treatment of cancer.invited u043cu043eu043du043eu043au043bu043eu043du0430u043bu044cu043du043eu0435 antibody, u0433u0443u043cu0430u043du0438u0437u0438u0440u043eu0432u0430u043du043du043eu0435,sections containing the constant heavy chain (sn) lgG1 rights and modified by the transfer of cd u0432u0430u0440u0438u0430u0431u0435u043bu044cu043du044bu0445 domains in u0432u0430u0440u0438u0430u0431u0435u043b mouse monoclonal antibodies u044cu043du044bu0435 plots (VH and vl) lgG1 manand, with increased u0430u0444u0444u0438u043du043du043eu0441u0442u044cu044e with u0430u043du0442u0438u043fu0440u043eu043bu0438u0444u0435u0440u0430u0442u0438u0432u043du043eu0439 activity, as well as the ability to activate the complement dependent u0446u0438u0442u043eu043bu0438u0437u0430 cells containing mole u043au0443u043bu044b CD20 surfaceas well as u0433u0438u0431u0440u0438u0434u043eu043cu0435, u043fu0440u043eu0434u0443u0446u0438u0440u0443u044eu0449u0435u0439 u043cu043eu043du043eu043au043bu043eu043du0430u043bu044cu043du043eu0435 antibody.the selected animals (female u0431u0435u0441u043fu0430u0442u043eu0433u0435u043du043du044bu0445 u0438u043cu043cu0443u043du043eu0434u0435u0444u0438u0446u0438u0442u043du044bu0445 mice line BALB / c NUDE) u043fu0440u043eu0442u0438u0432u043eu043eu043fu0443u0445u043eu043bu0435u0432u044bu0439 effect was expressed in tumor u0443u0437u043du0430u0432u0430u043du0438u0438, physical isolationthe lock functions associated u0440u0435u0446u0435u043fu0442u043eu0440u0430.in the application of the u043cu043eu043du043eu043au043bu043eu043du0430u043bu044cu043du043eu0433u043e antibodies on a u043fu0440u043eu0442u0438u0432u043eu043eu043fu0443u0445u043eu043bu0435u0432u044bu0439 response will be implemented on a wide range of functions, which implies the ability by more effective drugs.described u043fu043eu043bu0438u043du0443u043au043bu0435u043eu0442u0438u0434, encrypting the antibody, as well as u044du043au0441u043fu0440u0435u0441u0441u0438u043eu043du043du044bu0435 vectors and host cell to obtain antibodies to CD20 - u0430u043du0442u0438u0433u0435u043du0443.