MEDIATED RNA-INTERFERENCE INHIBITING THE EXPRESSION OF THE HOMEPHOLOGICAL GENE 1 BTB AND CNC, THE MAIN TRANSFCRIPTION FACTOR WITH LEUKIN LIGHTNING 1 (Bach1) USING SMALL INTERFACE

摘要

The present invention relates to compounds, compositions and methods for the study, diagnosis and treatment of signs, diseases and conditions responsive to modulation of gene expression and / or Bach1 activity and / or to modulate the expression path of the Bach1 gene. Specifically, the invention relates to double-stranded nucleic acid molecules, including small nucleic acid molecules, such as small interfering nucleic acid (miNK), small interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (μRNA) and short-chain RNA ( kshRNA) capable of mediating or mediating RNA interference (RNAi) against the expression of the Bach1 gene.