MODULATION OF TRANSACTIVATION OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) BY INHIBITING THE ACTIVITY OF AMPHIREGULIN AND USES THEREOF

摘要

The present invention relates to the modulation of transactivation of receptor tyrosine kinases by G protein or G protein-coupled receptor (GPCR) mediated signal transduction in a cell or an organism comprising inhibiting the activity of the metalloprotease TACE/ADAM17 and/or the activity of the receptor tyrosine kinase ligand amphiregulin.