POLYPEPTIDE OR POLYPEPTIDE CONSTRUCT COMPRISING AT LEAST ONE SINGLE DOMAIN ANTIBODY DIRECTED AGAINST VON WILLEBRAND FACTOR, A COMPOSITION COMPRISING IT, A NUCLEIC ACID ENCODING IT AND ITS USES IN THE PREPARATION OF A MEDICAMENT FOR PREVENTION AND/OR ALLEVIATION OF CONDITIONS OF PLATELET MEDIATED AGGREGATION

摘要

The present invention relates to polypeptides comprising at least one single domain antibody directed against vWF, vWF A1 domain, A1 domain of activated vWF, vWF A3 domain, gpIb and/or collagen, for the treatment for conditions which require a modulation of platelet-mediated aggregation. A further aspect of the invention is methods of production of said polypeptides, methods to coat devices with such polypeptides used in medical procedures (e.g. PCTA, stenting) and kits for the diagnosis of diseases related to platelet-mediated aggregation.