IBANDRONIC ACID MONOSODIUM SALT IN AMORPHOUS FORM, PHARMACEUTICAL COMPOSITIONS CONTAINING IT AND A PROCESS FOR ITS PREPARATION

摘要

The invention relates to a process for the preparation of diphosphonic acids by reaction of a carboxylic acid with a mixture of phosphorous acid and phosphorus oxychloride in defined molar ratios and in the absence of solvents. The invention futher relates to ibandronic acid monosodium salt in the amorphous form.