COMPOSITIONS COMPRISING REGULATORS OF THE HEDGEHOG PATHWAY FOR USE IN REGULATING DIFFERENTIATION OR PROLIFERATION OF CELLS, CONTROLLING THE GROWTH OR DEVELOPMENT OF PANCREATIC TISSUE AND TREATING A HYPERPROLIFERATIVE DISORDER

摘要

The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.