TWO NEW AMIDES WITH CYTOTOXIC ACTIVITY FROM THE FRUITS OF PIPER LONGUM

摘要

The invention provides two new minor amides, piperlongimin A (2) [2E-N isobutyl-hexadecenamide] and piperlongimin B (4) [2E-octadecenoylpiperidine] together with five known compounds with moderate cytotoxic activity by bioassay-guided fractionation of the fruits of Piper longum. The structures are elucidated on the basis of spectroscopic evidences. All these compounds inhibit cell proliferation of Human leukemia, HL-60 cell lines and display major apoptosis inducing effects.