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NOVEL PROCESS FOR PREPARING N-2-(DIETHYLAMINO)ETHYL-5-(Z)-(5-FLUORO-1,2- DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)METHYL-2,4-DIMETHYL-1H-PYROLE-3-CARBOXAMIDE SALTS
NOVEL PROCESS FOR PREPARING N-2-(DIETHYLAMINO)ETHYL-5-(Z)-(5-FLUORO-1,2- DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)METHYL-2,4-DIMETHYL-1H-PYROLE-3-CARBOXAMIDE SALTS
An improved process for preparing acid addition salts of N-[2-(diethylamino)ethyl]-5-[(Z)- (5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrole-3- carboxamide, in particular N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo- 3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrole-3-carboxamide-(2S)-2- hydroxybutanedioate (I). Compositions comprising N-[2-(diethylamino)ethyl]-5-[(Z)-(5- fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrole-3- carboxamide-(2S)-2-hydroxybutanedioate (I) and use of said compositions in the treatment of disease.
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