A DIRECT METHOD FOR PREPARING QUININE HYDROCHLORIDE FROM CINCHONA BARK.

摘要

The disclosure of invention relates to a cost effective and pharmaceutically acceptable process for the direct extraction method for quinine hydrochloride from Cinchona bark. In the present invention, wherein a mixture of Cinchona alkaloids were extracted with an organic solvent from Cinchona bark and the alkaloids were precipitated out from the acidified aqueous layer by adjusting optimal pH using NaOH solution. Precipitate was subjected to water purification and quinine hydrochloride was crystallized at ambient temperature.