CHITOSAN BASED NANOCOMPLEX FOR SUSTAINED DRUG DELIVERY

摘要

The present invention relates to the synthesis of BDMCA, a novel curcumin analog was loaded into biodegradable nanoparticles and its in-vitro release kinetics and in-vivo antidiabetic potential was evaluated. Nanoparticle formulations were characterized for entrapment efficiency, drug content, particles size, in vitro drug release and the drug-polymer interaction. The in-vivo antidiabetic property of the formulation was evaluated in streptozocin induced diabetic rats. The BDMCA loaded chitosan nanoparticles were successfully prepared using ion gelation technique. The particles were spherical in shape with smooth surface in scanning electron microscopy (SEM) image. Average mean size of the curcumin analog nanoparticles was found to be approximately within the range of 120-150 nm. FTIR datas of chitosan, CNP BDMCA and B-CNCs confirms the encapsulation of BDMCA in chitosan. The nanoparicle formulations effectively sustained the release of the drug was explained using invitro release kinetics. The antidiabetic activity of B-CNCs was comparable with that of the standard drug and also more efficient than un-encapsulated BDMCA.