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CHEMICAL REAGENTS FOR THE ACTIVATION OF POLYSACCHARIDES IN THE PREPARATION OF CONJUGATE VACCINES.
CHEMICAL REAGENTS FOR THE ACTIVATION OF POLYSACCHARIDES IN THE PREPARATION OF CONJUGATE VACCINES.
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机译:在制备共轭疫苗中活化多糖的化学试剂。
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摘要
This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include l-cyano-4-pyrrolidinopyridinium tetrafluoroborate (CPPT), 1-cyano-imidazole (1-CI), 1-cyanobenzotriazole (1-CBT), or 2-cyanopyridazine-3(2H)one (2-CPO), or a functional derivative or modification thereof. The examples illustrate the use of these reagents with a variety of polysaccharides and proteins showing that the methods are generally applicable.
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