Chimeric antibodies with part new world primate binding regions

摘要

Disclosed is a chimeric antibody polypeptide comprising an antigen binding site, wherein the antigen binding site comprises a human variable domain having at least one New World Primate CDR, wherein said New World Primate CDR has an amino acid sequence encoded by a sequence obtained from New World Primate DNA by PCR using primer pair VK1BL (SEQ ID NO:1l) / VK1BL35a (SEQ ID NO:12) or primer pair VK1BL (SEQ ID NO:11) / VK1BL35b (SEQ ID NO: 13).