CYCLIC DEPSIPEPTIDES FROM ISOLATED CHONDROMYCES CROCATUS USEFUL AS INHIBITORS OF KALLIKREIN 7 AND HUMAN NEUTROPHIL ELASTASE

摘要

Disclosed herein is a cyclic depsipeptide having the structure of formula (I), wherein an ester bond is formed between the carboxy group of A7 and the hydroxyl group of A2, wherein the acyl residue X is CH3CH2CH(CH3)CO or (CH3)2CHCO, A1 is glutamine, glutamic acid, or a derivative thereof, A2 is threonine,A3 is leucine, A4 is Ahp, 3-amino-piperidine-2-one, proline, 5-hydroxy-proline or a derivative thereof, A5 is isoleucine, A6 is tyroxine, N-Me-tyrosine or a derivative thereof, A7 is isoleucine or valine;or a pharmaceutically acceptable salt thereof. Also disclosed is the extraction of said compound from isolated Chondromyces microorganism from the strain Chrondromyces crocatus (DSM 19329) as well as an alternative process for its preparation.