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GENE EXPRESSION MARKERS (INHBA) FOR COLORECTAL CANCER PROGNOSIS

机译:基因表达标记(INHBA)用于大肠癌的预后

摘要

Disclosed is a method of predicting clinical outcome for a human subject following surgical resection of colorectal cancer, the method comprising: a.) Determining a normalised level of RNA transcript of INHBA, or an expression product thereof, in a biological sample comprising cancer cells obtained from said human subject; and b.) Predicting the likelihood of a positive clinical outcome for said human subject by comparing said normalised level to gene expression data obtained from colorectal cancer reference samples derived from patients with colorectal cancer, wherein increased normalised level of an RNA transcript of INHBA, or an expression product thereof, is negatively correlated with an increased likelihood of a positive clinical outcome.
机译:公开了一种预测大肠癌手术切除后人类受试者临床结局的方法,该方法包括:a。)在包含获得的癌细胞的生物学样品中确定INHBA RNA转录本或其表达产物的标准化水平来自所述人类对象;和b。)通过将所述标准化水平与得自结直肠癌患者的结直肠癌参考样品的基因表达数据进行比较来预测所述人受试者阳性临床结果的可能性,其中INHBA的RNA转录本的标准化水平升高,或其表达产物与阳性临床结果的可能性增加呈负相关。

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