Virostaticos compounds as inhibitors of dihydroorotate dehydrogenase

摘要

Refers to a compound of formula (i) where a is a ring aromatic or non aromatic hydrocarbon c5-c6 and optionally one or more carbon Atoms are replaced by a group X; l is a Union simple, NH; d is o, S, SO2, NR4, CH2; Z1 and Z2 are each one, S, NR5, R1 is H, halogen, haloalca Nile, haloalquenilo, among others; R2 is H, NH2, Oh, among others; R3 is H, alcanilo, alquenilo,Alquinilo, among others, cycloalkyl, aryl, heteroaryl R4 is H, cycloalkyl, among others; R5 is H, ho, alcaniloxi, alqueniloxi or aryl -, alcanilo, among others; R8 is H, alcanillo, alquenilo or alquinilo; X is s or n, NR4, SO2, so; and is H, halogen, haloalcanilo, haloalcaniloxi, among others; and S alquenilo, aryl, heteroaryl,Alquinilo or FUSED bicyclic or tricyclic Ring System; m, N, Q and R are each 0 - 1; t is 0-3.un Preferred Compound is acid, 3 - (2,3,5,6 - tetrafluoro - 3 '- Diphenyl - 4 - (trifluoromethoxy ilcarbamoil) - thiophene-3 - carboxylic acid. In addition to such a Pharmaceutical composition.This Compound is a dihidroorato dehydrogenase inhibitor used for the treatment and Prevention of Viral Diseases