Pyrethroid (1.4) benzodiazepine (1.4) as binary mixture of anticancer agents

摘要

The invention relates to a pyrrolo (1.4) benzodiazepine derivative prepared by (I),a. Dotted line represents simple o r double link; u and u'son h; W and w'son O H, o r, ocor, ocor, etc.; R 1, R2, R1 'and r2'son h, Hal, C1-C6 tar, etc.; E and y'son H-u; m is ch or N; ALK's C1-C6 tar; R and r'son h, C1-C6 tar, arilo, etc.; L is a l-1-l2 group;L1 i s alk-s, o-alk-nr3-alk-s, L2 is ch2c (= O) - NR3 - (CH2O) i-alk, among others, R3 is h or C1-C6 tar, I is an integer of 1-40, ZB is simple unanlace, O, NH, Rb is h, C1-C6 tar, C3-C7, etc. Dibenzo-dimethyl-di-di-dimethyl-dibenzo-di-di-diacrylonitrile (acrylonitrile) - etoxi (etoxi) - etoxi} - etoxiB]]]]]] - Di]]]]]] - methyl imine]]]] - methylene imine (imine (methylene imine propionic acid, N-hydroxy hydroxylamide, etc.). These compounds are useful in cancer treatment