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Process for obtaining high-purity prindoprile as well as intermediate compounds useful in a synthesis associated therewith
Process for obtaining high-purity prindoprile as well as intermediate compounds useful in a synthesis associated therewith
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机译:获得高纯度普利度普利以及与之相关的合成中有用的中间体化合物的方法
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摘要
The invention relates to 1-ä2(S)-Ä1(S)-(ethoxycarbonyl)butylaminoÜpropionylü-(3aS,7aS)octahydro indol-2(S)-carboxylic acid of the Formula I and the t-butylamine salt of the Formula I' thereof free of contaminations derivable from dicyclohexyl carbodiimide, and a process for the preparation thereof. The invention also relates to new intermediates of the general Formula III (wherein R stands for lower alkyl or aryl lower alkyl). The compound of the Formula I - perindopril - is a known ACE inhibitor.
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