首页> 外国专利> BIOPOLYMERIC DRESSINGS 'PROBIOS' FOR CURING WOUNDS AND PROCESS FOR PREPARING BIOPOLYMERIC DRESSINGS 'PROBIOS' FOR CURING WOUNDS

BIOPOLYMERIC DRESSINGS 'PROBIOS' FOR CURING WOUNDS AND PROCESS FOR PREPARING BIOPOLYMERIC DRESSINGS 'PROBIOS' FOR CURING WOUNDS

机译:用于伤口的生物聚合物涂料“ PROBIOS”以及用于伤口的生物聚合物涂料“ PROBIOS”的制备方法

摘要

The present invention relates to an absorbing composite which consists of a biopolymeric dressing and to a process for preparing such a product. According to the invention, the product is biodegradable, with three-dimensional conformation and porous micro-structure and consists of collagen proteins, hyaluronic acid, growth factors and pharmaceutical factors with protective role and activity for stimulating the tissular regeneration. According to the invention, the process comprises the step of preparing a collagen solution with a concentration of 0.6...2% and pH of 5...7. In a planetary mixer there are introduced 100 parts of 2% collagen solution and there are added 5 parts of 6% condroitin-6-sulphate solution, while stirring for 60 min at a temperature of 10° C and a pressure of 0.1 torr, then adding 0.0005 parts TGFb, 0.25% neomycin sulphate, and 100 parts of solution containing 0.02 g silver nitrate, continuing the homogenization for 60 seconds, there resulting a composition which is lyophilized in moulds at the desired dimensions, thereby producing elastic spongious white-coloured foils which are hermetically packaged and sterilized by exposure to UV and γ radiations.
机译:本发明涉及一种由生物聚合物敷料组成的吸收性复合材料,并涉及制备这种产品的方法。根据本发明,该产物是可生物降解的,具有三维构象和多孔的微结构,并且由胶原蛋白,透明质酸,生长因子和药学因子组成,具有刺激组织再生的保护作用和活性。根据本发明,该方法包括制备浓度为0.6 ... 2%且pH为5 ... 7的胶原蛋白溶液的步骤。在行星式混合机中,加入100份2%胶原蛋白溶液,并加入5份6%的condroitin-6-硫酸盐溶液,同时在10°C的温度和0.1 torr的压力下搅拌60分钟,然后加入0.0005份TGFb,0.25%新霉素硫酸盐和100份含有0.02克硝酸银的溶液,继续均质60秒,得到的组合物在模具中冻干至所需尺寸,从而生产出弹性海绵状白色箔。通过暴露于紫外线和γ来密封包装和灭菌辐射。

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