PROCESS FOR THE PREPARATION OF (ALPHA S, BETA R) -6-BROM-ALPHA-AE2- (DIMETHYLAMINO) ETHYL-2-METH XY-ALPHA-1-NAPHTHALINYL-BETA-PHENYL-3-CHINOLINETHANOL

摘要

The present invention relates to a process for isolating (S,R)-6-bromo--[2-(dimethylamino)ethyl]-2-methoxy--1-naphthalenyl--phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo--[2-(dimethylamino)ethyl]-2-methoxy--1-naphthalenyl--phenyl-3-quinolineethanol by optical resolution with chiral 4-hydroxydinaphtho[2,1-d:1,2-f][1,3,2]dioxaphosphepin 4-oxide or a derivative thereof, in particular (11bR)-4-hydroxydinaphtho[2,1-d:1,2-f][1,3,2]dioxaphosphepin 4-oxide, as resolution agent.