ARYLPYRIMIDINE SUITES FOR THE TREATMENT OF SEXUAL HORMONIC CONDITIONS SUCH AS ENDOMETRIOSIS, PROSTATE CANCER AND THE SAME

摘要

GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein n, RSUB1a/SUB, RSUB1b/SUB, RSUB1c/SUB, RSUB2a/SUB, RSUB2b/SUB, RSUB3/SUB, RSUB4/SUB, RSUB5/SUB, RSUB6 /SUBand X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.