therapeutic antibodies and induce tolerance.

摘要

modified therapeutic antibody comprising an antibody cell binding includes a combining site of the antibody that binds to a target antigen bound to cells being modified said antibody with a peptide that inhibits binding of the antibody to the target antigen, wherein the peptide comprises the target antigen or a domain or mimotope thereof which is reversibly bound to the antibody combining site, being effective to reduce said modified an immune response against the antibody and for producing a therapeutic effect by binding to the target antigen antibody.