Method of in vitro from patients with splenic marginal zone diagnosis.

摘要

Method of in vitro from patients with splenic marginal zone diagnosis. The present invention describes a method of in vitro diagnosis of SMZL based on the analysis of the expression of a series of localized in a very specific region deleted human chromosome 7 genes. The specific region deleted in patients with SMZL has been defined by using CGH arrays high affinity and is located at 7q22.1 between 99925039-101348479 bases, where the genes: TSC22D4, HRBL, LRCH4, MUC3, MUC12, SH2B2 , MUC17 and CUX1. Also in the present invention in vitro diagnostic kits of SMZL, comprising at least one probe that recognize the deleted region 7q22.1 or hybridize at least one of the nucleotide sequences of the genes described above.