USE OF AMATOXIN OR FALOTOXIN CONJUGATES WITH MACROMOLECULES FOR TUMOR THERAPY AND INFLAMMATION.

摘要

Conjugate of the general carrier-toxin formula, in which - the toxin is an amatoxin; and - the carrier comprises a tumor-specific monoclonal antibody that binds to or is absorbed by tumor cells; wherein the conjugate can be obtained by reacting the tumor-specific monoclonal antibody with 10 equivalents of β-amanitin-N-hydroxysuccinimide ester for 16 hours at 4 ° C.