NOVELTY DERIVATIVES OF PSAMMAPLIN A, A METHOD FOR YOUR SYNTHESIS AND ITS USE FOR THE PREVENTION OR TREATMENT OF CANCER.

摘要

Molecule of formula (I): where: n is an integer selected from 1, 2, 3, 4, 5, 6, 7, 8; i is an integer selected from 1, 2; j is a selected integer of 0.1; when i = 2, then j = 0 and when i = 1, then j = 1; X is a halogen atom; W is a binding group selected from: -CO-NH-, -NH-CO-, -CO-O-, -O-CO-, - CO-S-, -S-CO-, -CH = CH- , in covalent bond; R is a group selected from: a hydrogen atom, a C1-C6 alkyl group, a C1-C6 carboxyalkyl group; R1, R2, R3, identical or different are selected from: a hydrogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group. , a halogen atom, a hydroxyl group, a C1-C6 alkoxy group, a C1-C6 aminoalkyl group, a C1-C6 saturated heterocycloalkyl group, a C6-C12 aryl group, a C6-C12 aralkyl group, a C4 heteroaryl group -C12; R4 is selected from: a hydrogen atom, a C1-C6 alkyl group, a C2-C6 acyl group, a C6-C12 aryl group, a C6-C20 aralkyl group, a C4-C12 heteroaryl group; R5 is selected from: a hydrogen atom, a C1-C6 alkyl group, a C6-C20 aralkyl group; and its pharmaceutically acceptable salts.