microfluidic chip radioactively labeled molecules can be synthesized on a scale suitable for imaging in humans with positron emission tomography

摘要

integrated, automated microfluidic device comprising: a chemical reaction chip comprising: a substrate comprising a microfluidic network of flow channels; and cylindrical reaction chamber having a ratio of diameter over a greater height of about 3 and comprising at least one input channel and one output channel, the reaction chamber being configured to be in fluid communication with at least a flow channel; characterized by: a vent comprising at least two open ends and configured to be adjacent to the reaction chamber for evaporation of solvent from the reaction chamber, the vent comprising a radiator separate channels of the reaction chamber a gas permeable membrane.