Formulations comprising compounds related to jorumycin, renieramycin, safracin or saframycin and a disaccharide for the treatment of proliferative diseases

摘要

A pharmaceutical composition comprising a disaccharide and a compound of general formula (I): in which R1 is selected from the group consisting of -CH2-N (Ra) 2 and -CH2-ORa-, in which each Ra is selected regardless of the group consisting of H, alkyl-CO-, -haloalkyl-CO, cycloalkylalkyl-CO-, haloalkyl-O-CO-, arylalkyl-CO-, arylalkyl-CO-, -heteroaryl-CO, alkenyl-CO-, alkyl, alkenyl and acyl amino acid, or the two Ra groups, together with the N-atom of -CH2-N (Ra) 2 form a heterocyclic group; R2 is selected from alkyl-CO-, -cycloalkyl-CO- and haloalkyl-CO-; and R3 is OH or CN; or its pharmaceutically acceptable salt or stereoisomer, and in which the various groups may be substituted or unsubstituted in one or more positions available by one or more suitable groups such as R'OR ', = O, SR', SOR ', SO2R ', NO2, NHR', N (R ') 2, = N-R', NHCOR ', N (COR') 2, NHSO2R ', CN, halogen, C ( = O) R', CO2R ' , O (C = O) R ', in which each of the groups R' or the groups R 'are independently selected from the group consisting of hydrogen, OH, NO2, NH2, SH, CN, halogen, = O, C ( = O) H, C ( = O) alkyl, CO2H, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl and substituted aryl or unsubstituted and where such groups are in turn substituted, the substituents are chosen from among R'OR ', = O, SR', SOR ', SO2R', NO2, NHR ', N (R') 2, = N-R ', NHCOR', N (COR ') 2, NHSO2R', CN, halogen, C ( = O) R ', CO2R', O (C = O) R ', in which the R groups 'or each of the R groups' is selected in dependent on the group consisting of hydrogen, OH, NO2, NH2, SH, CN, halogen, -O, C (-O) H, C ( = O) alkyl, CO2H, unsubstituted C1-C12 alkyl, C2 alkenyl C12 unsubstituted, C2-C12 alkynyl unsubstituted and aryl unsubstituted.