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LIVE VACCINE CARRIER STRAINS USEFUL FOR HIGH LEVEL EXPRESSION OF HETEROLOGOUS O-ANTIGENS FROM GRAM-NEGATIVE PATHOGENS AND DERIVATIVES THEREOF FOR USE AS LIVE VACCINES
LIVE VACCINE CARRIER STRAINS USEFUL FOR HIGH LEVEL EXPRESSION OF HETEROLOGOUS O-ANTIGENS FROM GRAM-NEGATIVE PATHOGENS AND DERIVATIVES THEREOF FOR USE AS LIVE VACCINES
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机译:活疫苗载体菌株可用于革兰氏阴性病原菌高水平表达异源O型抗原,并衍生出其用作活疫苗
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摘要
The present invention relates to live attenuated gram-negative vaccine carrierstrains which are useful for expression and delivery of heterologous O-antigens (O-PS) from gram-negative pathogens. Said strains are deficient inthe expression of homologous O-PS due to a defined genetic modification,preferably a deletion, and, thus, capable of efficiently expressing a desiredheterologous O-PS in such a way that it is covalently coupled either tohomologous or heterologous LPS core lipid A. The present invention furthermorerelates to live vaccine carrier strains containing a heterologous gene or aset of heterologous genes encoding O-PS. Preferably, said strains additionallycontain genes necessary for the synthesis of complete smooth heterologous LPS.The present invention also relates to live vaccines comprising said strains,preferably for immunization against gram-negative enteric pathogens.
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