VASCULAR ENDOTHELIAL GROWTH FACTOR C (VEGF-C) PROTEIN AND GENE, MUTANTS THEREOF, AND USES THEREOF

摘要

Provided are purified and isolated VEGF-C polypeptides capable of binding toat least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptortyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like orVEGF-like biological activities or that are VEGF or VEGF-C inhibitors;polynucleotides encoding the polypeptides; vectors and host cells that embodythe polynucleotides; pharmaceutical compositions and diagnostic reagentscomprising the polypeptides; and methods of making and using the polypeptides.