GENETICALLY MODIFIED TUMOR-TARGETED BACTERIA WITH REDUCED VIRULENCE

摘要

The present invention is directed to mutant Salmonella sp. having agenetically modified msbB gene in which the mutant Salmonella is capable oftargeting solid tumors. The invention is also directed to Salmonella sp.containing a genetically modified msbB gene as well as a genetic modificationin a biosynthetic pathway gene such as the purI gene. The present inventionfurther relates to the therapeutic use of the mutant $I(Salmonella) for growthinhibition and/or reduction in volume of solid tumors.