BIOABSORBABLE POLYMERIC IMPLANTS AND A METHOD OF USING THE SAME TO CREATE OCCLUSIONS

摘要

An embolic, bioabsorbable polymeric material (BPM) is incorporated into a coilto improvelong-term anatomic results in the endovascular treatment of intracranialaneurysms. Thematerial includes at least one biocompatible and bioabsorbable polymer andgrowth factors,is carried by hybrid bioactive coils and is used to accelerate histopathologictransformationof unorganized clot into fibrous connective tissue in aneurysms. Anendovascular cellularmanipulation and inflammatory response are elicited from implantation in avascularlocation. Thrombogenicity of the biocompatible and bioabsorbable polymer iscontrolled bythe composition of or proportioning the ratio of constituents marking up thepolymer. Thebiocompatible and bioabsorbable polymer is at least one polymer selected forthe groupconsisting of polyglycolic acid, poly-glycolic acid/poly-L-lactic acidcopolymers,polycaprolactive, polyhydroxbutyrate/hydroxyvalerate copolymers, poly-L-lactide,polydioxanone, polycarbonates, and polyanhydrides.