USE OF THERAPEUTIC DOSAGES FOR NITRIC OXIDE DONORS WHICH DO NOT SIGNIFICANTLY LOWER BLOOD PRESSURE OR PULMONARY ARTERY PRESSURE

摘要

Patients with pathologic conditions involving constriction or proliferation ofsmooth muscle or disease associated with cysteine containing proteins, or whoare at risk for such, are administered a therapeutically effective amount of anitric oxide (NO) donor which is insufficient to acutely lower mean arterialblood pressure or pulmonary artery pressure by more than 10%. In one subgenus,NO donor is administered to modify red blood cell membrane receptors toprevent red blood cells from causing vasoconstriction. A related method whichallows increased dosage of NO donor without acutely lowering mean arterialblood pressure comprises administering the NO donor into an artery of thepatient. In another method, patients having a cardiovascular syndrome, or whoare at risk for such, are administered a therapeutically effective amount ofthiol which does not acutely affect blood pressure to a significant degree.