DEUTERATED GLUCOSE OR FAT TOLERANCE TESTS FOR HIGH-THROUGHPUT MEASUREMENT OF THE METABOLISM OF SUGARS OR FATTY ACIDS IN THE BODY

摘要

Provided herein are methods for determining the metabolism of one or moresugars and/or fatty acids, and applications thereof. Such applications includedetermining the rate of glycogen synthesis and glycolysis, which are believedto be early markers for predicting elevated risk of diabetes andcardiovascular disease. Other applications include methods for screening drugsthat effect sugar and/or fatty acid metabolism. The methods are useful for atleast partially characterizing drugs for desirable or undesirable (toxic)characteristics. Drugs that are at least partially characterized using themethods of the invention can then be further developed in preclinical testingand clinical trials. Such drugs may be found to be useful in treating obesity,diabetes, cardiovascular disease, and other disorders of metabolism.