Elimination of heterogeneous or mixed cell population in tumors

摘要

Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cellpopulations is described. The killing or inhibition of tumors is achieved byselectively targeting a unique ligand suspected of being expressed on a particular cellpopulation to also kill a cell population lacking the unique ligand. These conjugateshave therapeutic use as they are delivered to a specific cell population to killthese cells and the cytotoxic drug is released to kill non-targeted cells, therebyeliminating the tumor.