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Compounds, preparation process, and uses thereof used for interrupting reuptake of 5-hydroxytryptamine and norepinephrine or treating diseases such as depression et al.
Compounds, preparation process, and uses thereof used for interrupting reuptake of 5-hydroxytryptamine and norepinephrine or treating diseases such as depression et al.
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机译:用于中断5-羟基色胺和去甲肾上腺素的再摄取或治疗疾病例如抑郁症的化合物,制备方法及其用途。
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摘要
Compounds of the general formula (I), optical isomers, pharmaceutically acceptable salts,preparation process and uses thereof in which R1, R2, R3 and R4 are as defined inspecification are disclosed. Such compounds can be optical isomers or racemic mixturesand can be metabolically transformated into 1-[2-dimethylamine-1-(4-hydroxyphenyl)-ethyl]cyclohexanol withnew pharmaceutically active in vivo after administration, which can be usedfor treating diseases associated central nervous system such as depression etal. by interrupting reuptake of 5-hydroxytryptamine (5-HT ) and norepinephrine (NA) .
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