A process for manufacturing Rosuvastatin Potassium and crystalline and amorphous forms thereof

摘要

A process of manufacturing of Rosuvastatin Potassium of formula (1) is disclosed.The process comprises the steps of (a) treating Rosuvastatin protected compoundof formula (II) wherein R and R are same or different havingC-C carbon atom or hydrogen or R and Rcan combine together to afford a cyclic structure comprising a junction atomas carbon or metal atom such as Si (silicon); with an inorganic base of the kindsuch as herein described having potassium as cation in a suitable solvent to formRosuvastatin potassium; (b) isolating Rosuvastatin potassium.