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NOVEL CATIONIC LIPIDS WITH SHORT LIPID CHAINS FOR OLIGONUCLEOTIDE DELIVERY

机译：具有短脂质链的新型阳离子脂质，可用于寡核苷酸的递送

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摘要

The instant invention provides for novel cationic lipids with short lipid chains that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo while decreasing inflammatory toxicities.

机译：本发明提供了具有短脂质链的新型阳离子脂质，其可与其他脂质组分例如胆固醇和PEG-脂质结合使用，以与寡核苷酸形成脂质纳米颗粒，以促进细胞摄取和内体逃逸，并敲低靶mRNA 体外和体内，同时降低了炎症毒性。 展开▼

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公开/公告号WO2011043913A3

专利类型

公开/公告日2012-06-14

原文格式PDF

申请/专利权人 MERCK SHARP & DOHME CORP.;CAMERON MARK;DAVIS JENNIFER R.;WANG WEIMIN;
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申请/专利号WO2010US49420

发明设计人 WANG WEIMIN;CAMERON MARK;DAVIS JENNIFER R.;
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申请日2010-09-20

分类号C07C229/00;A61K9/127;

国家 WO

入库时间 2022-08-21 17:19:31

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3. NOVEL CATIONIC LIPIDS WITH SHORT LIPID CHAINS FOR OLIGONUCLEOTIDE DELIVERY [P] . 欧洲知识产权局专利： EP2485770A4 . 2013-04-10

机译：具有短脂质链的新型阳离子脂质，可用于寡核苷酸的递送

4. NOVEL CATIONIC LIPIDS WITH SHORT LIPID CHAINS FOR OLIGONUCLEOTIDE DELIVERY [P] . 欧洲知识产权局专利： EP2485770A2 . 2012-08-15

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5. NOVEL CATIONIC LIPIDS WITH SHORT LIPID CHAINS FOR OLIGONUCLEOTIDE DELIVERY [P] . 美国专利： US2012253032A1 . 2012-10-04

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