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AMINE FUNCTIONALIZED SUPERPARAMAGNETIC NANOPARTICLES FOR THE SYNTHESIS OF BIOCONJUGATES
AMINE FUNCTIONALIZED SUPERPARAMAGNETIC NANOPARTICLES FOR THE SYNTHESIS OF BIOCONJUGATES
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机译:胺功能超顺磁性纳米粒子用于生物缀合物的合成
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摘要
Amine functionalized magnetic nanoparticle compositions and processes for synthesizing the same are described. The process consists of obtaining a carboxylated polymer in substantially pure form, which is used to prepare a substantially size homogeneous, polymer coated carboxyl, functionalized magnetic nanoparticle. The carboxyl groups are converted to reactive primary amino groups by the use of a water-soluble carbodiimide followed by reaction of a large excess of a diamine. The amine-terminated nanoparticles are then reacted with bifunctional crosslinking agents and with various biomolecules to make nanoparticles for in vitro assays, cell sorting applications and target specific MR contrast agents.
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