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COLONIZATION FACTOR (CF) ANTIGENS OF ENTEROTOXIGENIC ESCHERICHIA COLI IN RECOMBINANT BACTERIA
COLONIZATION FACTOR (CF) ANTIGENS OF ENTEROTOXIGENIC ESCHERICHIA COLI IN RECOMBINANT BACTERIA
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机译:重组细菌中肠毒素大肠杆菌的定殖因子(CF)抗原
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摘要
Escherichia coli strains, such as enterotoxigenic E. coli strains, genetically engineered to express from recombinant plasmids one or more colonization factors (CFs) associated with enterotoxigenic Escherichia coli bacteria (ETEC) in an increased amount compared to said CFs expressed by ETEC wild-type reference strains, as well as a method of producing such strains, and vaccine compositions against diarrhea comprising such strains, are described. Further, E. coli strains expressing unnatural combination of at least two different CFs, e.g., CFA/I+CS2, CFA/I+CS6, or CS2+CS4 are disclosed.
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机译:大肠杆菌菌株,例如产肠毒素的大肠杆菌菌株,经过基因工程改造后可以从重组质粒表达与产肠毒素的大肠杆菌(ETEC)相关的一种或多种定殖因子(CF),与通过ETEC野生型表达的所述CF相比,其表达量增加描述了参考菌株,以及产生此类菌株的方法,以及包含此类菌株的腹泻疫苗组合物。此外,公开了表达至少两种不同CF的非天然组合的大肠杆菌菌株,例如CFA / I + CS2,CFA / I + CS6或CS2 + CS4。
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