首页> 外国专利> ANTIGEN PEPTIDE FOR SUPPRESSING METASTASIS, ANTI-METASTATIC VACCINE INCLUDING SAME, COMPOSITION FOR SUPPRESSING AND TREATING METASTASIS, AND METHOD FOR SCREENING METASTASIS-RELATED TARGET MATERIALS AND METASTASIS SUPPRESSANT

ANTIGEN PEPTIDE FOR SUPPRESSING METASTASIS, ANTI-METASTATIC VACCINE INCLUDING SAME, COMPOSITION FOR SUPPRESSING AND TREATING METASTASIS, AND METHOD FOR SCREENING METASTASIS-RELATED TARGET MATERIALS AND METASTASIS SUPPRESSANT

机译：用于抑制转移的抗原肽，包括该抗原的抗转移疫苗，用于抑制和治疗转移的组合物以及筛选与转移有关的靶材料和转移抑制剂的方法

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摘要

The objective of the present invention is to provide a technical basis for Epitin to control the progression and metastasis of cancer using a vaccine or antibodies, by identifying the correlation between the amount of Epitin expression and vascular endothelial cell permeation movement by means of using various cancer stem cells, and to provide an antigen peptide and an anti-metastatic vaccine including same, which are proven to induce antibodies and suppress metastasis in in vitro and in vivo tests based on the technical basis.

机译：本发明的目的是通过使用多种癌症来识别表素表达量与血管内皮细胞渗透运动之间的相关性，从而为表素使用疫苗或抗体控制癌症的进展和转移提供技术基础。干细胞，并提供一种抗原肽和包括该抗原肽的抗转移疫苗，经证明可在体外和体内试验的基础上诱导抗体并抑制转移技术基础。 展开▼

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公开/公告号WO2012060480A1

专利类型

公开/公告日2012-05-10

原文格式PDF

申请/专利权人 INHA-INDUSTRY PARTNERSHIP INSTITUTE;KIM MOON-GYO;LEE DEOK-JAE;KIM CHUNG-HO;LEE HYO-SEON;
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申请/专利号WO2010KR07634

发明设计人 KIM MOON-GYO;LEE DEOK-JAE;KIM CHUNG-HO;LEE HYO-SEON;
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申请日2010-11-02

分类号C07K7/06;C07K7/08;A61K38/08;A61K38/10;A61P35;

国家 WO

入库时间 2022-08-21 17:16:10

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1. 包含P34的表达抑制剂或活性抑制剂作为有效成分的用于治疗或转移抑制癌的组合物 [P] . 中国专利： CN105283206B . 2019.11.08

2. 包含P34的表达抑制剂或活性抑制剂作为有效成分的用于治疗或转移抑制癌的组合物 [P] . 中国专利： CN105283206A . 2016-01-27

3. ANTIGEN PEPTIDE FOR SUPPRESSING METASTASIS, ANTI-METASTATIC VACCINE INCLUDING SAME, COMPOSITION FOR SUPPRESSING AND TREATING METASTASIS, AND METHOD FOR SCREENING METASTASIS-RELATED TARGET MATERIALS AND METASTASIS SUPPRESSANT [P] . 韩国专利： KR101500670B1 . 2015-03-10

机译：用于抑制转移的抗原肽，包含相同抗原的抗转移疫苗，用于抑制和治疗转移的组合物以及筛选与转移有关的靶标材料和转移抑制剂的方法

4. (54) Title: SUPPRESSION OF CANCER METASTASIS (57) Abstract: Methods are provided for suppressing cancer metastasis. Cancer metastasis is the most common cause of treatment failure and death in cancer patients. Tumor cell invasion and/or migration can be significantly inhibited after fibrillar proteins (rVPl, F-HSA, and F-BSA) treatment in vitro. In addition, rVPl can significantly suppress murine and human breast cancer metastasis and human prostate and ovarian cancer metastasis in vivo while F-HSA can significantly suppress murine breast cancer metastasis. Compositions of fibrillar proteins as anti-cancer metastasis therapeutics and methods of use thereof are provided herein. [P] . IN2012MN01463A . 2012-08-24

机译：（54）标题：抑制癌转移（57）摘要：提供了抑制癌转移的方法。癌症转移是癌症患者治疗失败和死亡的最常见原因。在体外处理原纤维蛋白（rVP1，F-HSA和F-BSA）后，肿瘤细胞的侵袭和/或迁移可以得到显着抑制。另外，rVP1可以在体内显着抑制鼠和人乳腺癌的转移以及人前列腺和卵巢癌的转移，而F-HSA可以显着地抑制鼠的乳腺癌的转移。本文提供了作为抗癌转移治疗剂的原纤维蛋白的组合物及其使用方法。

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机译：糖尿病视网膜病变的血管生成抑制剂，抑制转移的药物，抑制黑素瘤的转移和治疗的药物

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