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TERNARY COMPLEX, LIQUID CONTAINING TERNARY COMPLEX, PREPARING METHOD AND USE THEREOF

机译:三元络合物,含三元络合物的液体,制备方法及其用途

摘要

A ternary complex comprising component A, B, C is provided, wherein the component A is a carrier with positive charge, the component B is a nucleic acid with negative charge, and the component C is a copolymer with negative charge. Liquid containing the ternary complex and preparing method thereof are also provided. The ternary complex and the liquid containing the ternary complex can improve the transfection efficiency and decrease the toxicity simultaneously, therefore can be used in cell transfection, prophylaxis or diagnosis of disease, and gene therapy.
机译:提供了包含组分A,B,C的三元配合物,其中组分A是带正电荷的载体,组分B是带负电荷的核酸,组分C是带负电荷的共聚物。还提供了含有三元络合物的液体及其制备方法。该三元复合物和含有该三元复合物的液体可同时提高转染效率并降低毒性,因此可用于细胞转染,疾病的预防或诊断以及基因治疗。

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