METHOD FOR DETECTING ALK GENE REARRANGEMENT AND METHOD FOR DIAGNOSING CANCER USING THE SAME

摘要

The present invention relates to a method for detecting ALK gene rearrangement, which is induced by ALK gene translocation, according to the overexpression of ALK protein after ALK antibody response, and a cancer diagnostic method using the same. The method for detecting ALK gene rearrangement according to the present invention provides a method for screening ALK gene rearrangement, which can primarily and efficiently identify targets for ALK inhibitors quickly and accurately by analyzing the overexpression of ALK protein, by suggesting a specific protocol for ALK antibody response and criteria for the analysis of IHC staining patterns as means of detection which makes up for the disadvantages of conventional FISH which is expensive and consumes long time. Accordingly, the present invention can broaden the range of therapies aimed at molecular targets.