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Use of ID4 for diagnosis and treatment of cancer

机译：ID4在癌症诊断和治疗中的用途

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摘要

Methods for diagnosis and treatment of cancer using ID4 are disclosed. Specifically, epigenetic inactivation of ID4 in colorectal carcinomas and breast correlates with poor differentiation and unfavorable prognosis. Further, aberrant hypermethylation of ID4 gene promoter region increases risk of metastasis in colorectal and breast cancer.

机译：公开了使用 ID4 诊断和治疗癌症的方法。具体来说， ID4 在结直肠癌和乳腺癌中的表观遗传失活与分化差和预后不良有关。此外， ID4 基因启动子区域的异常甲基化增加了结直肠癌和乳腺癌转移的风险。 展开▼

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公开/公告号EP2272984B1

专利类型

公开/公告日2012-06-20

原文格式PDF

申请/专利权人 WAYNE JOHN CANCER INST;
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申请/专利号EP20100166653

发明设计人 HOON DAVE S. B.;UMETANI NAOYUKI;
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申请日2006-02-01

分类号C12Q1/68;C07H21/02;C07H21/04;

国家 EP

入库时间 2022-08-21 17:15:33

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