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RECOMBINANT BACTERIUM COMPRISING A TOXIN/ANTITOXIN SYSTEM
RECOMBINANT BACTERIUM COMPRISING A TOXIN/ANTITOXIN SYSTEM
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机译:包含毒素/抗毒素系统的重组细菌
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摘要
The present invention encompasses recombinant bacteria suitable for live attenuated vaccines, and methods of use thereof. One aspect of the present invention encompasses a recombinant Salmonella bacterium. The bacterium comprises a first promoter operably linked to a nucleic acid encoding a toxin and a second promoter operably linked to a nucleic acid encoding an antitoxin, wherein the second promoter is inactive in vivo, but active in vitro.
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