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Modulating drug release rate by controlling the kinetics of the pH transition in hydrogels
Modulating drug release rate by controlling the kinetics of the pH transition in hydrogels
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机译:通过控制水凝胶中pH跃迁的动力学来调节药物释放速率
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摘要
Methods and compositions relate to modulating the release profile of drug molecules from a hydrogel by controlling the kinetics of the pH transition of the hydrogel. The hydrogel is formed by in situ polymerization and includes a drug molecule having a pKa between the pH of the formed hydrogel and the physiologic environment in which the hydrogel is placed.
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