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COMPOUND CHINESE MEDICINE EXTRACT USED FOR PREVENTING AND TREATING ARTERIOSCLEROSIS AND PREPARATION METHOD THEREOF

机译:用于预防和治疗动脉硬化的复合中药提取物及其制备方法

摘要

Disclosed is a compound Chinese medicine extract used for preventing and treating arteriosclerosis, which comprises the following active components: ceryl alcohol, beta-sitosterol, hexacosanic acid, atractylenolide Ⅲ, oleanolic Acid, berberine, jatrorrhizine, coptisine, salvianic acid A, salvianolic acid B, cyclotetracosane, 9,12-linoleic acid, 5,7-dimethoxycoumarin, Specnuezhenide, ginsenoside Rb1 and Rg1, notoginsenoside R1, eucommiol, etc. The said extract is prepared from the raw medicines of danshen root, glossy privet fruit, coptis root, Japanese thistle herb or root, eucommia bark, largehead atractylodes rhizome, panax notoginseng, and bergamot, through mixing effective fractions extracted by organic solvents with different polarity from the total extract of the raw medicine which is extracted by C1-3 alcohol and/or water. Because of elimination of large quantities of noneffective components, the content of the effective components increases largely, and the influence of noneffective components to product processing and formulation quality is decreased. The preparation method is stable and available for mass production with controllable product quality.
机译:公开了一种用于预防和治疗动脉硬化的复合中药提取物,其包含以下活性成分:神经醇,β-谷甾醇,六葡糖酸,白术内酯Ⅲ,齐墩果酸,小碱,香根草碱,黄连,丹参酸A,丹参酸B ,环四烷,9,12-亚油酸,5,7-二甲氧基香豆素,Specnuezhenide,人参皂苷Rb1和Rg1,三七皂苷R1,杜仲醇等。所述提取物是从丹参根,有光泽的女贞子,黄连,日本蓟药草或根,杜仲皮,大头白术,三七和佛手柑,通过混合用极性不同的有机溶剂从有效成分中提取的有效级分从原料药的总提取物中提取而来,总原料由C1-3酒精和/或水提取。由于消除了大量无效组分,有效组分的含量大大增加,并且降低了无效组分对产品加工和制剂质量的影响。制备方法稳定,可用于批量生产,产品质量可控。

著录项

  • 公开/公告号WO2012094832A1

    专利类型

  • 公开/公告日2012-07-19

    原文格式PDF

  • 申请/专利号WO2011CN70313

  • 发明设计人 GUO JIAO;TANG CHUNPING;

    申请日2011-01-17

  • 分类号A61K31/7048;A61K31/704;A61K31/575;A61K31/56;A61K31/4375;A61K31/352;A61K31/343;A61K31/201;A61K31/20;A61K31/192;A61K31/015;A61K36/752;A61P9/10;

  • 国家 WO

  • 入库时间 2022-08-21 17:14:48

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