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METHOD FOR PREPARING DERIVATIVES OF NITRIC-OXIDE-DONOR GLYCOSAMINOGLYCANS, THE RESULTING NITRODERIVATIVES AND THE USE THEREOF IN THE TREATMENT OF CHRONIC ULCERS
METHOD FOR PREPARING DERIVATIVES OF NITRIC-OXIDE-DONOR GLYCOSAMINOGLYCANS, THE RESULTING NITRODERIVATIVES AND THE USE THEREOF IN THE TREATMENT OF CHRONIC ULCERS
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机译:一氧化氮供体糖基氨基糖聚糖的衍生物的制备方法,产生的氮衍生物及其在慢性溃疡治疗中的用途
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摘要
The invention relates to a method for preparing derivatives of nitric-oxide-donor glycosaminoglycans, the resulting nitroderivatives and the use thereof in the treatment of chronic ulcers, such as diabetic foot ulcers, ulcers caused by burns and pressure ulcers. More specifically, the invention relates to methods for preparing nitroderivatives of unfractionated heparin (UFH), derivatives of low molecular weight heparins (LMWH) and derivatives of very low molecular weight heparins (VLMWH), all of which have a nitric oxide donor ability, and to the use thereof in the production of a drug for the treatment of chronic ulcers and, in particular, diabetic foot ulcers, ulcers caused by burns and/or pressure ulcers.
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