C-ABL TYROSINE KINASE INHIBITORS USEFUL FOR INHIBITING FILOVIRUS REPLICATION

摘要

This disclosure provides method of treating a Filoviridae viral infection, such as an Ebola virus infection or a Marburg virus infection, comprising providing an effective amount of a c-Abl tyrosine kinase inhibitor to a patient in need thereof. The c-Abl tyrosine kinase inhibitor may be a biological inhibitor that decreases expression of the c-Abl tyrosine kinase, such as a c-Abl tyrosine kinase specific siRNA. However it is preferred that the c-Abl tyrosine kinase inhibitor is a small molecule c-Abl tyrosine kinase antagonist. Suitable c-Abl tyrosine kinase antagonists include dasatinib, imatinib, and nilotinib and the pharmaceutically acceptable salts thereof.